Research Associate II

Who We Are:

At Neoleukin Therapeutics, we are dedicated to developing medicines that transform lives. We believe that there is an urgent need for a paradigm shift in therapeutic protein discovery that overcomes a reliance on the building blocks that nature has provided. Our innovative computational platform allows us to design entirely new – de novo – proteins from the ground up to treat serious diseases, including cancer, inflammatory, and autoimmune disorders. We are a team of physicians, scientists, and innovators with a visionary focus to improve on nature and enable a truly customized approach to medicine. We are leading the protein design revolution. We invite you to join us on this journey.

The Opportunity: Research Associate II, Downstream Process Development

The Research Associate II is a hands-on laboratory-based role in protein purification. The individual will be required to perform designed experiments, problem solving, and to work independently. This role is expected to be onsite 5 days a week with core hours of 9:00am to 5:00pm.

What You’ll Do:

• Execution, optimization and troubleshooting of preestablished experimental designs
• Characterization of biological molecules using analytical and biochemical assays
• Partnering with our R&D groups to maintain and expand our de novo protein portfolio
• Assisting with laboratory setup and maintenance duties
• Documents of methods, data and results into electronic notebook (ELN)
• Perform downstream unit operations including cell lysis, filtration, chromatography, and ultrafiltration/diafiltration
• Screen chromatography resins, buffers and operating parameters
• Recording, analyzing data, writing technical reports, and conclusions.
• Discuss data, draw preliminary conclusions, and design next experiments with colleagues and managers
• Maintain laboratory equipment, supplies and work area

What You’ll Bring:

• BS/MS in biological sciences (Biochemistry, Bioengineering, Cell Biology, Chemistry, Molecular Biology or a related field)
• Hands-on downstream experience
• 2+ years’ experience in process development oriented lab
• Must be able to independently prepare buffers following batch record
• Experience performing SDS-PAGE required
• Ability to problem solve and identify work to be done pro-actively
• Attention to detail and strong work ethic
• Excellent written and oral communication skills
• Excitement about the vision and mission of Neoleukin Therapeutics
• Skilled in Excel data entry and plotting
• Experience with downstream process development and chromatography equipment AKTA, homogenizer, and TFF system.
• Excellent record keeping, record, analyze, and document process development data.

Neoleukin Employer Highlights:

• Strong Culture: Our values are foundational to our culture. Neoleukin is values and mission-driven with passionate co-workers, supportive managers, flexibility, and care for the employee as a whole person.
• Trailblazing Research: Neoleukin is a pioneer in de novo protein development, leveraging computational methods to create new therapies. Neoleukin’s lead program, NL-201, is believed to be the world’s first computationally-designed de novo protein therapeutic.
• Holistic Benefits: 3 weeks PTO, week off for winter break, sick leave, 8 weeks parental leave plus state/federal leave, comprehensive health coverage, employee assistance program, transportation and cell phone benefit, stock options and 401k match.
• Exciting Office Environment: From free onsite gym access, a bike storage locker, an office espresso machine and regular opportunities to gather – Neoleukin is a fun place to work!

To protect the safety of our employees and the larger community, Neoleukin requires all new hires who will perform on-site work to submit proof of full vaccination against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.

Neoleukin Therapeutics is proud to be an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status, or age, and Neoleukin will not tolerate discrimination or harassment based on any of the above characteristics.