Principal Scientist, Computational Genomics

Job Description

General Summary:

The Computational Genomics Principal Research Scientist collaborates with cross-functional project teams to design studies, analyze and interpret large-scale genomics data, and communicate results that will have a critical impact on the development of cutting-edge, transformative therapies. The incumbent is self-reliant with a formidable record of accomplishments, independently identifying and solving tough problems repeatedly, across a number of critical and diverse projects. The incumbent will innovate pro?ciently and generate insights that in?uence research strategies. Incumbent should be regarded as an emerging expert in a ?eld of research, providing reliable, valuable advice to other research Project Teams on a regular basis. The incumbent will exhibit an ability to make signi?cant conceptual contributions.

Key Duties and Responsibilities:

• Designs and performs sophisticated, technically challenging work, ef?ciently and independently
• Generates effective hypotheses to pursue Project goals and set new experimental directions
• Identi?es broad implications to ?ndings, which transcend the immediate experiment
• Develops novel and creative solutions to overcome Project goal obstacles
• Performs advanced, complex experimental troubleshooting and methods development, and is routinely called upon to use this prowess to assist others outside of own Projects
• Makes substantive conceptual contributions to Project activities and scienti?c strategies
• “Imports” new principles/concepts from other ?elds to establish new progress in Projects
• Coordinates publication and/or patenting of ?ndings, or is a major contributor to these processes
• Provides authoritative, technical recommendations broadly within the company regarding own ?eld/discipline, and often occupies a key or pivotal formal or informal Project role
• May be the practical manager of CRO contracts or external collaborative research
• Performs other duties as assigned
• May supervise other Research staff

Knowledge and Skills:

• Deep knowledge in the analysis, visualization, and interpretation of genomic and next-generation sequencing (NGS) data
• In-depth scientific understanding of gene editing, the role of genetic variation in human disease, molecular biology, and cellular biology
• Expertise with applying computational methods and bioinformatics tools to large-scale data
• In-depth understanding of statistics

Education and Experience:

• Ph.D. (or equivalent degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field, and 4-7 years of productive, relevant post-doctoral employment experience, or
• Master's Degree (or equivalent degree) in similar fields, and 7+ years of productive, relevant employment experience, or
• Bachelor's Degree (or equivalent degree) in similar fields, and 10+ years of productive, relevant employment experience
• Typically requires 7 years of experience or the equivalent combination of education and experience
• A superior communicator, demonstrating the ability to write advanced technical documents and demonstrating con?dence and versatility in presenting verbally to diverse audiences
• Demonstrates advanced judgment, balancing technical feasibility and scienti?c opportunity/impact
• Regularly executes technically challenging, complex experiments successfully within project expectations
• Discerns new, productive paths in experiments with great regularity
• Demonstrates initiative and ability to capitalize on scienti?c creativity and insights
• Assigned to the more challenging or higher-value Project tasks/problems
• Demonstrates outstanding determination and/or persistence in supporting Project(s)

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com.