Employment Type : Full-Time
Overview: About Torbett Lab and Projects The laboratory of Dr. Bruce E. Torbett is looking for a Research Scientist III to be a workstream leader in projects related to Lentiviral Vector Engineering and Improved Gene Delivery methodologies to hematopoietic stem cells (HSCs). This translational work aims to improve the delivery of therapeutic genes and gene-modifying agents for the purpose of genetic correction as well as the prevention of viral infections. The candidate will be involved in setting up and managing studies to determine restrictions of lentiviral vector (LV) entry to HSCs and how they can be overcome by using small molecule transduction enhancers (PMID 24914132, 31416800), alternate surface envelopes (PMID 30603655), or engineering improved producer cell lines. Ideal Candidate will have a Ph. D. in Cell/Molecular Biology related field with documented experience in production and use of lentiviral vectors in primary cells, preclinical testing of LV gene therapy in humanized mouse models, as well as familiarity with standard virology techniques. The group works as a highly dynamic and interactive team and is part of the Center for Immunity and Immunotherapies (CIIT) of Seattle Children's Research Institute (SCRI). Our studies are funded through a number of grants from the NIH (including the flagship HIVE Center) as well as from the Gates Foundation. You will have the opportunity to interact and form collaborations with CIIT, SCRI and HIVE Center Investigators, as well as with collaborators throughout the Seattle area (University of Washington, Fred Hutch) Seattle Children's Research Institute and Torbett Lab offer competitive salaries, relocation assistance (if/as applicable), in addition to eligibility to a competitive benefits package as a full time employee About the Position Preferred Qualifications: Hope. Care. Cure. These three simple words capture what we do at Seattle Children's - to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible. Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine. Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report's top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems. We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you. Our community welcomes diverse experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our increasingly diverse patients and families. Our organization recruits, employs, trains, compensates, and promotes without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics. The people who work at Seattle Children's are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves within this community, which cultivates and promotes equity, diversity, and inclusion at all levels. Seattle Children's is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.
Requirements