Principal Scientist, Biomarker Development/Translational Science (remote) Details

Principal Scientist, Biomarker Development/Translational Science (remote)

Corbus Pharmaceuticals - Norwood, MA

Employment Type : Full-Time

Company Description

Corbus Culture:

Our passion. Our purpose. At Corbus, it starts at our core.

We look for unique talent. Our people are brilliant, they break barriers and are not defined by a title. Eclectic experiences make Corbus a special place to share ideas and grow. At Corbus, transformative ideas can come from anyone, anywhere and anytime. We offer our team flexibility and the opportunity to excel in their professional journey. We provide a welcoming space where collaboration, mentorship and diversity are encouraged. We come together, like no other, to elevate each other and focus on what’s best for patients.

About Corbus

Corbus is committed to leveraging our expertise in immunology to fulfill our purpose of developing innovative new medicines that improve the lives of people living with inflammatory, fibrotic, and metabolic diseases, and cancer. Corbus’ current pipeline includes small molecules that activate or inhibit the endocannabinoid system and anti-integrin monoclonal antibodies that block activation of TGF?. Corbus is headquartered in Norwood, Massachusetts. For more information on Corbus, visit corbuspharma.com. Connect with us on Twitter, LinkedIn and Facebook.

Corbus Pharmaceuticals Holdings, Inc. is an equal opportunity employer

The Principal Scientist will be responsible for the development and execution of preclinical research to advance our biologic assets in immune oncology. The successful applicant will be an exceptional scientist capable of directing research efforts and collaborating with KOLs and CROs with a specific focus on developing therapies targeted to the tumor microenvironment. The scientist will design studies to assess on-target effects on tumor and immune biology with the goal of developing companion diagnostic and biomarker strategies for predicting and enhancing responsiveness to checkpoint blockade and other combination therapies. The Senior Scientist will work under the direction of the Project Leader and work collaboratively with CROs as well as leading academic labs. The successful candidate will publish and present research results at annual research conferences and become a KOL in their own right.

Responsibilities:

• Design, develop, and implement translational biomarkers assays both independently and in collaboration with others in a team-based environment.
• Collaborate in a highly matrixed environment to drive and support translational clinical research activities with both research and clinical development colleagues, and contribute to program translational research strategies.
• Develop and implement patient selection strategies in support of Phase I clinical trials
• Coordinate and manage clinical biomarker assay transfer and development activities with Contract Research Organizations (CROs)/vendors.
• Independently drive and support clinical trial biomarker data analysis and interpretation. Prepare technical reports, summaries, protocols, and quantitative analyses and communicate these results regularly at team meetings.
• Stay current with scientific and translational literature and investigate, create, and develop novel methods and technologies for project advancement.

Required Skills/Experiences:

• Ph.D. in Cancer Biology, Pharmacology, Immunology or related scientific discipline.
• 8+ years post graduate experience in pharmaceutical research and development in the fields of oncology and immunology with at least 2 years of experience in a clinical translational biomarker role
• Demonstrated expertise across a wide range of cellular, protein, and molecular analytical platforms and assays including receptor occupancy (RO), immunoassays (ELISA, MSD, Luminex), and PD assays and a strong background and knowledge of multiparameter flow cytometry (FACS).
• Experience with biopsy material, and immunohistochemical and genetic approaches to defining tumor characteristics.
• Experience in developing clinical assays aimed at evaluating peripheral biomarkers
• Experience working with and analyzing large datasets
• Experience with assay transfer, development, and validation as well as CRO vendor management.
• Excellent skills in networking with external partners to identify, evaluate and execute on new opportunities for strategic collaboration/investment
• An outstanding publication/patent record.
• Exceptional knowledge of scientific area of responsibility
• Demonstrates creativity and novel approaches to solving scientific problems
• Excellent written and oral communication skills
• Motivation to bring novel treatments to patients in need

All your information will be kept confidential according to EEO guidelines.