Principal Bioinformatics Scientist Details

Principal Bioinformatics Scientist

Ambry Genetics - Aliso Viejo, CA

Employment Type : Full-Time

Job Overview:
Ambry Genetics is seeking an experienced Bioinformatics Scientist to work closely with biologists, bioinformaticians, and clinicians to design, develop, validate, and maintain bioinformatics pipelines and applications that can run on-premise as well as the cloud. The Principal Bioinformatics Scientist will lead a team of Bioinformatics Scientists responsible for delivering bioinformatics solutions to support the analysis of clinical samples.

• Manage a team of Bioinformatics Scientists to develop new methods and maintain bioinformatics software solutions
• Provide guidance and mentorship for junior-level team members and make technical decisions
• Establish project goals, milestones and timelines of deliverables for clinical product development and new assay validation
• Provide bioinformatics support to R&D and Clinical Lab by analyzing and interpreting Next Generation Sequencing (NGS) data
• Lead in NGS data analysis, bioinformatics pipeline QA/QC, and troubleshooting and improvement for bioinformatics pipelines and applications for clinical tests

JOB SPECIFICATIONS

• PhD degree in bioinformatics, computational biology, biophysics, biology and computer science, or related discipline plus at least 2 years postdoc/industrial experience
• MS degree in bioinformatics, computational biology, biophysics, biology and computer science, or related discipline plus at least 5 years industrial experiences is required
• Knowledge of cancer genomics and human genetics
• Familiar with molecular biology, biological pathways, and genomics
• Strong knowledge of current theories and principals of bioinformatics and computational biology

• Knowledge in the cutting-edge tools and technologies used in the field of NGS
• Ability to rationalize the uses and identify limitations of different tools, technologies and platforms in the field of NGS
• Knowledge in the sample workflows (web and dry labs) in a diagnostic setting
• Ability to understand, interpret, and visualize and communicate NGS analysis result
• Proficiency with at least one programming language (Python, Perl, R, C/C++, Java) in Linux/Unix environment
• Proficiency in the use of bioinformatics databases (COSMIC, TCGA, RefSeq, dbSNP, ClinVar, etc)
• Ability to read and write a variety of structured/semi-structured formats (example: XML, JSON, CSV, TSV)
• Experiences with HPC and storage systems in cloud-based and on-premise computing environments
• Experience in Illumina sequencing data, bioinformatics NGS pipelines and public domain tools (BWA, SAMTools, Bowtie2, STAR, TopHat, Picard, PINDEL, GATK, CNVKit etc.)
• Experiences with relational databases such as MySQL, PostgreSQL or Microsoft SQL Server
• Working knowledge of code repository best practices and distributed version control (example: git/Subversion)
• Excellent oral and written communication skills
• Ability to work within a team, among cross-departments, and as a team-level contributor, requiring minimal supervision

• At least 5 years of experience working with NGS data
• At least 5 years of experience in bioinformatics systems and software developments
• At least 2 years mentoring experience

About Us

Ambry Genetics Corporation is a CAP-accredited and CLIA-licensed molecular genetics laboratory based in Aliso Viejo, California. We are a genetics-based healthcare company that is dedicated to open scientific exchange so we can work together to understand and treat all human disease faster.

At Ambry, everyone is welcome. A career at Ambry Genetics is a chance to be part of a dynamic company that aims to improve health by understanding the relationships between genetics and human disease. We earned our reputation as industry leaders by responsibly introducing cutting-edge genetic testing solutions and continually sharing what we learn with the global scientific community.

At Ambry you will be learning, challenging yourself, and having fun while collaborating with teammates through the open exchange of ideas. Our outstanding benefits program includes medical, dental, vision, 401k, FSA, and generous paid time off (PTO) program. Ambry Genetics is an Equal Opportunity Employer (EOE) and we maintain a drug-free work environment.

Ambry Genetics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race (and traits historically associated with race, including, but not limited to hair texture and protective hairstyles such as braids, locks, and twists), color, creed, religion, sex, sexual orientation, gender identity, gender expression (including transgender status), national origin, ancestry, age, marital status or protected veteran status and will not be discriminated against on the basis of disability, protected medical condition as defined by applicable state or local law, genetic information, or any other characteristic protected by applicable federal, state, or local laws and ordinances.

Ambry does not accept unsolicited resumes from individual recruiters, third party recruiting agencies, outside recruiters or firms without an executed contract in place. We are not responsible for any fees related to resumes that are unsolicited or are received by Ambry. Such resumes will be deemed the sole property of Ambry and will be processed accordingly.