Associate Scientist II, Synthetic vRNA Process Development Details

Associate Scientist II, Synthetic vRNA Process Development

Oncorus - Andover, MA

Employment Type : Full-Time

Oncorus is a clinical-stage biotechnology company focused on developing next-generation viral immunotherapies to transform outcomes for cancer patients. Based in the vibrant Kendall Square and Andover, MA biotech ecosystem and backed by group of leading institutional life sciences investors, we are advancing a portfolio of intratumorally and intravenously administered viral immunotherapy candidates based on our oncolytic herpes simplex virus-1 and synthetic virus platforms for multiple indications with significant unmet needs. Our team is driving innovation and engineering multiple candidates with both platforms to potentially enable us to deliver on the full potential of this exciting therapeutic class. We believe every cancer patient deserves a better outcome. And we’re working with urgency to make that happen. Please visit www.oncorus.com to learn more.

Overview:

Oncorus is seeking a highly motivated and skilled candidate for the role of Associate Scientist II for our viral RNA process development team. The candidate will focus on developing robust and scalable processes for in vitro transcribed RNA and purification of synthetic virus active pharmaceutical ingredients. The candidate will have an opportunity to get on the ground level and grow significantly with the program. An ideal candidate will be a self-starter, scientifically motivated and capable of performing day to day lab operations with minimal supervision.

Full vaccination against COVID-19 is a requirement and essential function of this position. The Company conducts background/reference checks and confirmation of vaccination for COVID-19 as part of its employment process and any offer of employment is contingent upon satisfactory completion of the foregoing checks and confirmation.

Responsibilities:

• Perform laboratory experiments to contribute to the optimization and downstream purification of in vitro transcribed (IVT) RNA.
• Carry out synthetic RNA scale-up development studies and toxicology batches in a GLP environment.
• Support analytical characterization of RNA products to assess identity, purity, and stability.
• Willing to support LNP formulation and characterization to evaluate safety and efficacy of RNA as needed.
• Effectively communicate development activities with internal groups.
• Work collaboratively both internally and externally to accomplish program goals and meet project timelines.
• Present findings and experimental plans to both the development and cross functional teams.
• Execute protocols, record laboratory data, and contribute to technical reports.

Qualifications:

• B.S. in Engineering, Chemistry or Pharmaceutical Science required.
• B.S. degree with 1-3 years of relevant industry experience. New graduates with less industry experience will be considered.
• Basic understanding of Chemistry and Biochemistry required.
• Previous laboratory experience is required.
• Prior experience using DoE to optimize multi-variable enzyme reaction space is desirable.
• Prior experience in downstream purification development (e.g., chromatography and filtration) is desirable.
• Experience producing, purifying and/or analyzing in-vitro transcribed (IVT) RNA highly desired.
• Prior experience with an array of analytical techniques to characterize RNA/DNA (e.g., DLS, fluorescent assays, CE, ELISA, U/HPLC) is a plus.
• Effective verbal and written communication skills.

Benefits and Perks:

• Oncorus, Inc. offers a comprehensive benefits package including health, dental, life insurance, 401k + company match, unlimited vacation and much more.
• Salary: commensurate with role and experience.

Oncorus is an EEO employer committed to an exciting, diverse, and enriching work environment. We recruit and employ individuals without regard to race, color, religion, creed, national origin, age, gender, sex, sexual orientation, gender identity, marital status, military or veteran status, disability, genetic information, or any other category protected by applicable federal, state or local law. The company may provide reasonable accommodations to employees on the basis of disability or religion, as required by law.

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